Can Nasal Polyps Cause Cancer ?
In multivariate analyses, which controlled for smoking, asthma, allergic rhinitis, and other factors, the relative risk of participants with nasal polyps developing NCPS was slightly attenuated, with a hazard ratio (HR) of 6.24, as well as for nasopharyngeal cancer, with an HR of 1.58, compared with controls.
Nevertheless, the association between the presence of nasal polyps and heightened risk of both NCPS and nasopharyngeal cancer remained positive even among participants who had never smoked, they note.
In older individuals, "the nasal polyp–cancer relationships were consistently significant regardless of [the presence] of asthma comorbidity," the investigators point out.
They also observed a trend, albeit weaker, between nasal polyps and certain head and neck cancers and comorbid allergic rhinitis. As they note, allergic rhinitis is another proxy marker for local type 2 inflammation.
"When nasal polyps are found in older patients, the potential risk of NCPS or nasopharyngeal cancer might need to be considered," concludes corresponding author Woo-Jung Song, MD, PhD, division of allergy and clinical immunology, University of Ulsan College of Medicine in Seoul, Korea, and colleagues.
However, they also caution that further studies are needed to elucidate the potential mechanisms between the development of head and neck cancer and the presence of nasal polyps in older patients, as well as to validate any potential causal relationship.
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Read more : How to Cure Nasal Polyps Naturally at Home ?
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